- 1914: HBU began as Hollandsche Bank voor Zuid-Amerika under the patronage of the Rotterdamsche Bank. The bank opened in Buenos Aires under the name of Banco Holand�s de la Am�rica del Sud.
- 1916: Banco Holand�s opened a branch in Rio de Janeiro.
- 1919: Banco Holand�s opened a branch in S�o Paulo. Rotterdamsche and Zuid-Amerika formed Hollandsche Bank voor de Middellandsche Zee. Hollandsche Bank voor West-Indi� was established with headoffice in Amsterdam to operate branches in Cura�ao. Original shareholders included the Royal West India Mail/Royal Netherlands Steamship Company and the subsidiary of Royal Dutch Shell which ran Cura�ao's refinery, as well as the Bank of Suriname, the Nederlandsche Haandels Matshappij, and the Rotterdam Bank Association.
- 1920: Hollandsche Bank voor de Middellandsche Zee opened branches in Genoa, Barcelona, Marseilles, Constantinople, and later Tel Aviv.
- 1920: Hollandsche Bank voor West-Indi� (HBWI) opened a branch in Caracas, the first branch of a European bank.
- 1922: Zuid-Amerika operated branches in Genoa, Hamburg, Buenos Aires, Rio de Janeiro, Santos, Santiago, S�o Paulo and Valparaiso.
- 1933: Hollandsche Zuid-Amerika merged with Hollandsche Bank voor de Middellandsche Zee to form Hollandsche Bank-Unie (HBU).
- 1935: HBU acquired HBWI, together with its branches in Willemstad and Caracas.
- 1939: HBU acquired G. von Dantzig & co.
- 1941: HBU acquired de s’Gravenhaagsche Creditvereeniging en Depositkas.
- 1952: HBU established a branch in Uruguay.
- 1954: HBU established a branch in Beirut.
- 1957: HBU maintained branches in the Netherlands, Neth. Antilles, Argentina, Brazil, Israel, Turkey, Uruguay, Venezuela, and Suriname.
- 1965: HBU established a branch in Paraguay. At this point it also had branches in Ecuador.
- 1967: At some point after the 6-Day War, HBU closed its branches in Israel.
- 1968: Algemene Bank Nederland acquired HBU but the overseas branches continued to operate under the HBU name. HBU also maintained branches in Aruba.
- 1969: HBU merged its Netherlands Antilles branches with Aruba Commercial Bank (est. 1949), Bonaire Commercial Bank (est. 1962), and Edwards, Henriques & Co. (est. 1856). All the banks were affiliates of ABN. The new bank’s name became Antilliaanse Bank Unie.
- 1972: ABN absorbed all HBU's overseas branches.
- 2001: ABN sold the Ecuadorian operation inherited from HBU to Banco del Pichincha (est. 1906).
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